The objective of this paper is to research ship design under the scope of the educational background provided by a school of architecture. The means by which we attempt to approach this aspect of ship design is the scenario of the rebuilding and retrofitting of an already existent ro -pax ferry into a small hospital ship intended to serve the island complex of the Aegean Sea, because according to the study of the problems of the health system at this region, it appears that such an infrastructure at the region would contribute to the advances in medical care there. Furthermore, such a concept ensures that the general dimensions and mechanical characteristics of such ship would enable it to approach, moor and perform even at the smallest of harbors, and on the other hand that the extent of the structural rebuilding would enable to express the intended architectural qualities. Regarding to these, and according to the established building program, particular attention is given to the proper location and design of required spaces, taking into account a number of design provisions considered in order to ensure a high standard of living, working and medical care within the ship. Additionally, attention was given to the optimal design and location of the public and support places of the health center, as well as to the flows within and between the decks of the vessel. Finally, the study contains fire safety and life-saving device plans, aiming at a wider and more comprehensive approach to the design of a vessel as functional hospital ship.